multiple sclerosis and narcolepsy with cataplexy

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Jennum PJ, Kornum BR, Issa NM,et al (2016) Monozygotic twins discordant for narcolepsy type 1 and multiple sclerosis. Lorenzoni PJ, Werneck LC, Crippa AC et al (2017) Is there a relationship between narcolepsy, multiple sclerosis and HLA-DQB1*06:02? Arq Neuropsiquiatr 75:345–348 Handb Clin Neurol 133:317–326Įkbom K (1966) Familial multiple sclerosis associated with narcolepsy. Silber MH (2016) Autoimmune sleep disorders. Nishino S, Kanbayashi T (2005) Symptomatic narcolepsy, cataplexy and hypersomnia, and their implications in the hypothalamic hypocretin/orexin system. J Clin Sleep Med 10:1025–1031īarateau L, Lopez R, Arnulf I et al (2017) Comorbidity between central disorders of hypersomnolence and immune-based disorders. Am J Epidemiol 165:1097–1109īrass SD, Li CS, Auerbach S (2014) The underdiagnosis of sleep disorders in patients with multiple sclerosis. Schmidt H, Williamson D, Ashley-Koch A (2007) HLA-DR15 haplotype and multiple sclerosis: a HuGE review. Kamm CP, Uitdehaag BM, Polman CH (2014) Multiple sclerosis: current knowledge and future outlook. Sleep 35:1247–1255īernard-Valnet R, Yshii L, Quériault C et al (2016) CD8 T cell-mediated killing of orexinergic neurons induces a narcolepsy-like phenotype in mice. Lancet Neurol 14:318–328Īndlauer O, Moore H IV, Hong SC et al (2012) Predictors of hypocretin (orexin) deficiency in narcolepsy without cataplexy. Liblau RS, Vassalli A, Seifi A, Tafti M (2015) Hypocretin (orexin) biology and the pathophysiology of narcolepsy with cataplexy. Goldbart A, Peppard P, Finn L, Ruoff CM, Barnet J, Young T, Mignot E (2014) Narcolepsy and predictors of positive MSLTs in the Wisconsin Sleep Cohort. Silber MH, Krahn LE, Olson EJ, Pankratz VS (2002) The epidemiology of narcolepsy in Olmsted County, Minnesota: a population-based study. Hublin C, Kaprio J, Partinen M, Koskenvuo M, Heikkila K, Koskimies S, Guilleminault C (1994) The prevalence of narcolepsy: an epidemiological study of the finnish twin cohort. The elucidation of underlying genetic and immune mechanisms needs further studies. The rarity of reports on this association probably reflects underrecognition.

In addition to NwC secondary to hypothalamic demyelination, some patients present a coexistence of MS with NC without detectable hypothalamic lesions.

A positive effect of steroids, immunoglobulins or natalizumab on narcolepsy symptoms was observed in four patients. (2) Coexisting type (18 pts): MS preceding or following the appearance of NC with SOREM, hypocretin deficiency but no lesions in the hypothalamus.

Two different types of association were identified: (1) Symptomatic type (5 pts): MS preceding the onset of narcolepsy, which was always without cataplexy (NwC) sleep onset REM episodes (SOREM) and hypocretin deficiency were observed in some, and lesions in the hypothalamus in all patients. ResultsĪ total of 26 patients (pts), 6 in the survey and 20 in the literature were found. International multicenter sleep center survey and literature review on narcolepsy with (NC) and without (NwC) cataplexy. The co-occurrence of narcolepsy with other autoimmune disorders (including multiple sclerosis, MS) is rare. There are increasing data suggesting the involvement of the immune system in narcolepsy.

Multiple sclerosis and narcolepsy with cataplexy